Free tool · No account
Clinical trials for colorectal cancer
Colorectal cancer trials increasingly test targeted and immune therapies, some limited to tumors with specific features like MSI-high status or a KRAS/BRAF mutation. A recent genomic report helps narrow the field.
1,537 recruiting trials. Showing a sample.
- recruitingPhase 2NCT06540326
Clinical Study of Second-line Treatment in Advanced Colorectal Cancer With Chemotherapy With Bevacizumab or Cetuximab
Guidelines recommend FOLFIRI in combination with bevacizumab or cetuximab as a treatment option for advanced second-line colorectal cancer, and this study explores the efficacy and safety of a clinical study of liposomal irinotecan (II), fluorouracil, in combination with bevac...
Listed by the study for Colorectal Cancer Metastatic. Record updated 2025-12-22.
Sponsored by Second Affiliated Hospital, Zhejiang University, School of MedicineFull details on ClinicalTrials.gov → - recruitingNANCT07254910
Feasibility of a Multi-Channel Intervention to Promote Colorectal Cancer Screening Among American Indians in Oklahoma
The Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS) Program addresses major regional CRC screening disparities among AI in Oklahoma. The investigators are engaged in a participatory and collaborative effort with Tribal Nations, Ar...
Listed by the study for CRC Screening. Record updated 2026-07-30.
Sponsored by University of OklahomaFull details on ClinicalTrials.gov → - recruitingPhase 2NCT07162714
SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal Cancer
Primary Objectives： Evaluate the complete response rate (CR rate) and safety of short - course radiotherapy combined with ivonesimab (AK112) in patients with pMMR/MSS mid - low rectal cancer. Secondary Objectives： Evaluate treatment - related toxic reactions, the quality of l...
Listed by the study for Rectal Cancer. Record updated 2026-08-07.
Sponsored by Zhejiang Cancer HospitalFull details on ClinicalTrials.gov → - recruitingPhase 2NCT06848348
Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain
A randomized study to determine safety and efficacy of a series of subcutaneous (SC) injections of HAL in patients with CINP, compared to matching placebo injections. After that, subjects may have the option to enter an Open Label extension phase, where available, in which all...
Listed by the study for Colorectal Neoplasms. Record updated 2026-05-29.
Sponsored by Dogwood Therapeutics Inc.Full details on ClinicalTrials.gov → - recruitingNCT07280143
The Development of MASLD Among Survivors of Breast or Colorectal Cancer
A metabolic issue is a condition where the body has problems with converting food into energy, using energy or storing energy properly. Examples of metabolic issues include obesity, diabetes, or high blood pressure MASLD -Metabolic-associated steatotic liver disease - also kn...
Listed by the study for Colorectal (Colon or Rectal) Cancer Survivors. Record updated 2025-12-12.
Sponsored by University of BernFull details on ClinicalTrials.gov → - recruitingPhase 1NCT06307249
Precision Therapy for Solid Tumors: Synergistic CDK4/6 Inhibition and Anti-VEGF Targeting LncRNA
Solid tumors pose significant challenges in current therapeutic approaches. Targeted therapy has emerged as a promising avenue, aiming to enhance treatment efficacy while minimizing adverse effects. This clinical trial focuses on an innovative combination of two targeted inhib...
Listed by the study for Colorectal Cancer. Record updated 2024-03-12.
Sponsored by Lebanese UniversityFull details on ClinicalTrials.gov → - recruitingPhase 3NCT06566755
Cadonilimab (AK104) Combined With Chemotherapy and Bevacizumab as First-line Treatment for RAS Mutated or Right Sided-metastatic MSS Colorectal Cancer
The purpose of this study is to assess the efficacy and safety of Cadonilimab (AK104) combined with chemotherapy and bevacizumab as first-line treatment for patients with RAS mutated or right sided-metastatic MSS colorectal cancer
Listed by the study for Colorectal Cancer. Record updated 2024-08-22.
Sponsored by Caigang LiuFull details on ClinicalTrials.gov → - recruitingNCT06403540
The Impact of Laparotomy and Analgesia Methods on Diaphragm
Major abdominal surgeries are traditionally performed via laparotomy. Analgesia is routinely administered during the postoperative period. The goal is to investigate the effects of laparotomy and analgesia methods on diaphragm function.
Listed by the study for Colorectal Neoplasms. Record updated 2025-04-30.
Sponsored by Prof. Dr. Cemil Tascıoglu Education and Research Hospital OrganizationFull details on ClinicalTrials.gov → - recruitingPhase 3NCT05236972
PACE: PD-1 Antibody For dMMR/MSI-H Stage III Colorectal Cancer
In this open-label phase III study, patients with local advanced colon cancer (TanyN+ ,M0, dMMR/MSI-H, at least 10cm from the anus verge)will be scheduled to Group A: receive anti-PD-1 antibody alone (8 cycles, 200mg iv drip Q3W) and Group B (4 or 8 cycles of XELOX: oxaliplati...
Listed by the study for Colorectal Carcinoma. Record updated 2022-12-30.
Sponsored by Sun Yat-sen UniversityFull details on ClinicalTrials.gov → - recruitingPhase 1NCT05803382
Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers
This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with the usual treatment with capecitabine in treating patients with cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or canno...
Listed by the study for Metastatic Colorectal Carcinoma. Record updated 2026-08-31.
Sponsored by National Cancer Institute (NCI)Full details on ClinicalTrials.gov →
Data from ClinicalTrials.gov, retrieved 2026-09-16. Study sponsors write and update their own records there, including the recruitment status shown here, and the U.S. government does not review or approve every study listed. A trial showing up here is not a recommendation and not a determination that anyone qualifies. Eligibility is decided by the trial's own doctors.
Refine for your situation
Add whatever you know: an age, a city, a mutation from a pathology report. We'll narrow the list to trials that fit. Describe it in your own words.
Trials for other conditions
What we will never do with your records
This generator runs without an account, and KeptWell itself makes the same promises to every family, regardless of plan or price.
- We won't sell your data.
- Not to advertisers, not to data brokers, not to insurers, not to pharma, not to anyone, in any form, ever.
- We won't train AI models on your records.
- KeptWell does not opt in to model training. OpenAI and Anthropic do not use API inputs or outputs to train their models by default.
- We won't lock you in.
- You can export everything in your circle as a ZIP at any time. Cancellation is one click.
Common questions
- Is this colorectal cancer trial finder really free?
- Yes. You describe the situation, we search ClinicalTrials.gov and show what matches. No account, no payment, no email required. Nothing you type is saved.
- Does showing up here mean the patient qualifies?
- No. A listing here is not a recommendation, and the U.S. government does not review or approve every study on ClinicalTrials.gov. These are trials worth asking your care team about. Every trial has detailed eligibility criteria that the trial's own doctors evaluate, and many depend on test results and treatment history that only your medical team knows in full.
- How current is this list?
- The trials come directly from ClinicalTrials.gov and are refreshed daily, with the retrieval date shown under the list. Each study record is written and kept up to date by that study's own sponsor, so the recruitment status is what the sponsor last reported. Each result links to the full, live record, and the finder above always runs a fresh search when you use it.
- What should I do with a trial that looks promising?
- Bring it to your oncologist or care team, and mention the NCT number (the ID that starts with NCT). They can tell you whether it is a genuine fit and refer you to the trial site.
Found trials worth discussing? Keep them next to the records.
The next step is a conversation with the care team, and that goes better when the scans, labs, and trial details live in one place everyone in the family can see. That's what KeptWell is: the binder, but it understands what's inside.
Get started
We'll email you a secure sign-in link. It works whether you're new here or already have an account.