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Clinical trials for head and neck cancer
Head and neck cancer trials often depend on HPV status and where in the head or neck the cancer started. Both shape which studies are a fit.
904 recruiting trials. Showing a sample.
- recruitingNANCT05919290
HN-QUEST: A Study of Head and Neck Imaging Biomarkers
This is a multi arm, single center, investigator initiated study to investigate online adaptive radiotherapy and biomarker development in patients with newly diagnosed HNSCC (Head and Neck Squamous Cell Carcinoma) receiving curative therapy. The study will consist of two pros...
Listed by the study for Head and Neck Squamous Cell Carcinoma. Record updated 2026-03-05.
Sponsored by University Health Network, TorontoFull details on ClinicalTrials.gov → - recruitingPhase 1, Phase 2NCT07109726
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
This is a Phase 1/2, open-label, multicenter study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics and anti-tumor activity of TER-2013 in patients with advanced solid tumors harboring AKT/PI3K/PTEN pathway alterations.
Listed by the study for Head and Neck Squamous Cell Carcinoma. Record updated 2026-08-21.
Sponsored by Terremoto Biosciences Inc.Full details on ClinicalTrials.gov → - recruitingPhase 3NCT05772208
Intensified Treatments for Patients With Locally Advanced Nasopharyngeal Carcinoma With Detectable EBV DNA After One Cycle GP Regime Neoadjuvant Chemotherapy
The goal of this multicenter randomized non-inferior study is to compare the additon of camrelizumab or nimotuzumab to neoadjuvant chemotherapy followed by concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma patients whose EBV DNA remained detectable afte...
Listed by the study for Nasopharyngeal Carcinoma. Record updated 2023-03-16.
Sponsored by Fudan UniversityFull details on ClinicalTrials.gov → - recruitingPhase 2NCT06470217
Tirilizumab with Albumin-bound Paclitaxel and Cisplatin for Locally Advanced Resectable Oral Squamous Cell Carcinoma
The dosing regimen in the trial group was: tirilizumab with albumin-bound paclitaxel and cisplatin for 3 preoperative Cycles. After neoadjuvant therapy, patients underwent surgery and were stratified according to pathological conditions after surgery; if significant pathologic...
Listed by the study for Locally Advanced Head and Neck Squamous Cell Carcinoma. Record updated 2025-02-11.
Sponsored by Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityFull details on ClinicalTrials.gov → - recruitingPhase 2NCT05686226
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
This is a phase II clinical trial to assess the clinical activity of immunotherapy with E7 TCR-T cells for metastatic HPV-associated cancers. HPV-associated cancers in include cervical, throat, penile, vulvar, vaginal, anal, and other cancers. Participants will receive a condi...
Listed by the study for Oropharyngeal Neoplasms. Record updated 2026-06-12.
Sponsored by Christian HinrichsFull details on ClinicalTrials.gov → - recruitingPhase 2NCT07090317
Iparomlimab and Tuvonralimab in HNSCC
This study is a single center, non-randomized, prospective phase II clinical trial to evaluate the efficacy and safety of Iparomlimab and Tuvonralimab in patients with with recurrent/metastatic head and neck squamous cell carcinoma failed second-line treatment. The participant...
Listed by the study for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma. Record updated 2026-06-18.
Sponsored by Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityFull details on ClinicalTrials.gov → - recruitingNANCT04475640
Cancer Genetic Testing in Ethnic Populations
This clinical trial examines the integration of cancer genetic testing in various ethnic populations. Studying individuals and families at risk of cancer may help identify cancer genes and other persons at risk. The information from this study may provide an opportunity for ca...
Listed by the study for Head and Neck Carcinoma. Record updated 2026-04-02.
Sponsored by Mayo ClinicFull details on ClinicalTrials.gov → - recruitingNCT06744296
Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck
This study will test the ability of a personalized blood test to determine which head and neck cancer patients will have a recurrence after treatment.
Listed by the study for Squamous Cell Carcinoma of Head and Neck. Record updated 2025-05-18.
Sponsored by Massachusetts Eye and Ear InfirmaryFull details on ClinicalTrials.gov → - recruitingPhase 3NCT05815927
Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer
This is a randomized open-label multicentre phase III superiority study of the effect of adding SABR to the standard of care treatment pembrolizumab on progression free survival in patients with oligometastases of a squamous cell carcinoma of the head and neck (SCCHN), histolo...
Listed by the study for Oligometastatic Squamous Cell Carcinoma of the Head and Neck. Record updated 2026-05-28.
Sponsored by European Organisation for Research and Treatment of Cancer - EORTCFull details on ClinicalTrials.gov → - recruitingPhase 4NCT07405086
Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study
This phase IV trial is evaluating whether morning versus afternoon administration of standard of care immunotherapy impacts its effectiveness in treating patients with solid tumors that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts...
Listed by the study for Advanced Head and Neck Squamous Cell Carcinoma. Record updated 2026-06-12.
Sponsored by OHSU Knight Cancer InstituteFull details on ClinicalTrials.gov →
Data from ClinicalTrials.gov, retrieved 2026-09-16. Study sponsors write and update their own records there, including the recruitment status shown here, and the U.S. government does not review or approve every study listed. A trial showing up here is not a recommendation and not a determination that anyone qualifies. Eligibility is decided by the trial's own doctors.
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Common questions
- Is this head and neck cancer trial finder really free?
- Yes. You describe the situation, we search ClinicalTrials.gov and show what matches. No account, no payment, no email required. Nothing you type is saved.
- Does showing up here mean the patient qualifies?
- No. A listing here is not a recommendation, and the U.S. government does not review or approve every study on ClinicalTrials.gov. These are trials worth asking your care team about. Every trial has detailed eligibility criteria that the trial's own doctors evaluate, and many depend on test results and treatment history that only your medical team knows in full.
- How current is this list?
- The trials come directly from ClinicalTrials.gov and are refreshed daily, with the retrieval date shown under the list. Each study record is written and kept up to date by that study's own sponsor, so the recruitment status is what the sponsor last reported. Each result links to the full, live record, and the finder above always runs a fresh search when you use it.
- What should I do with a trial that looks promising?
- Bring it to your oncologist or care team, and mention the NCT number (the ID that starts with NCT). They can tell you whether it is a genuine fit and refer you to the trial site.
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